POS0150 BEING OVERWEIGHT IS ASSOCIATED WITH NOT REACHING LOW DISEASE ACTIVITY IN WOMEN BUT NOT MEN WITH PSORIATIC ARTHRITIS

Background: Disease manifestations and outcomes of psoriatic arthritis (PsA) seem to differ between sexes. Gaining knowledge about the underlying mechanisms these differences men women is important optimize treatment strategies, especially given that less often reach low disease activity (LDA) targets 1,2 . Objectives: To assess sex in parameters health-related quality life PsA, whether determinants associated with not reaching target differed women. Methods: A cross-sectional study was conducted, using data from a routine practice cohort 855 patients were all tightly monitored treated. Gender respect Psoriatic Arthritis Activity Score (PASDAS), skin/nail disease, SF12-PCS, SF12-MCS, inflammatory backpain (IBP), demographics assessed. Multivariate analyses used examine PASDAS ≤3.2 Results: Women had worse scores for - among others- swollen tender joints, CRP, enthesitis, function (all P<0.001). Higher found than men, mean 3.5 (SD=1.5) vs 2.7 (SD=1.5), p<0.001. Likewise, more at (OR = 2.03, Besides being female, also presence nail IBP, higher number DMARDs past or current used, Body Mass Index (BMI) overall sample. No medication use Table 1 shows women, but BMI (BMI 25-30: OR =3.6, P<0.001; 30-35: OR=2.41, P=0.023; >35: OR=2.45, P=0.002). Conclusion: PsA treated setting have severe men. This demonstrated by both subjective objective measures, addition target. Notably, overweight References: [1]Theander E, Husmark T, Alenius GM, Larsson PT, Teleman A, Geijer M, et al. Early arthritis: short symptom duration, male gender preserved physical functioning presentation predict favourable outcome 5-year follow-up. Results Swedish Register (SwePsA). Ann Rheum Dis. 2014;73(2):407-13. [2]Orbai AM, Perin J, Gorlier C, Coates LC, Kiltz U, Leung YY, Determinants Patient-Reported Impact Disease: An Analysis Association 458 Patients 14 Countries. Care Res (Hoboken). 2019. 1. Final multivariate logistic regression model stratified Variable Men (N 465) 390) (95% CI) P-value 25-30 kg/m 2 (ref: <25) 3.6 (1.86-6.99) <0.001 30-35 2.41 (1.12-5.14) 0.023 >35 2.45 (1.40-4.28) 0.002 Presence 1.57 (0.97-2.55) 0.066 IBP 2.75 (1.13-6.70) 0.026 3.22 (1.52-6.85) MCS (SF12) 0.93 (0.90-0.95) 0.96 (0.94-0.98) 0.001 cDMARD no DMARD) 1.16 (0.58-2.31) 0.671 bDMARD 0.49 (0.23-1.02) 0.057 Number history 1.36 (1.17-1.59) 1.13 (1.02-1.25) 0.015 1.90 (1.11-3.24) 0.018 * <0.05 considered significant. score; body mass index; backpain; SF12-MCS form-12 mental component scale; conventional DMARD; biological disease-modifying antirheumatic drug. Disclosure Interests: None declared